منابع مشابه
Drug-related hepatotoxicity.
N Engl J Med 2006;354:731-9. Copyright © 2006 Massachusetts Medical Society. In this review, we define hepatotoxicity as injury to the liver that is associated with impaired liver function caused by exposure to a drug or another noninfectious agent. The distinction between injury and function is important, because it is mainly when function is impaired that symptoms and clinically significant d...
متن کاملDrug metabolism and hepatotoxicity.
Drug metabolism in the 1960s At the time the Liver Unit was established in 1966, interest in the study of drug metabolism was growing, stimulated largely by the pharmaceutical industry, and the legislative requirements imposed upon it. It represented a remarkable change from the situation a few years previously when'. . . the study ofthe metabolism of foreign compounds was not a popular one; bi...
متن کاملDrug-induced hepatotoxicity.
N Engl J Med 2003;349:474-85. Copyright © 2003 Massachusetts Medical Society. n the past five years, two drugs have been withdrawn from the market by the Food and Drug Administration (FDA) for causing severe liver injury, a potential danger that had not been fully recognized in the course of the preapproval clinical trials. Reports of adverse drug reactions of any type engender fear and skeptic...
متن کاملDrug and Alcohol Induced Hepatotoxicity
Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the United States. Ethanol (EtOH) causes a further substantial amount of liver insufficiencies world wide. The current thesis was focused on the mechanisms behind hepatotoxicity caused by these agents. Using...
متن کاملAnti-Tuberculosis Drug-Induced Hepatotoxicity: A Review
Hepatotoxicity, a serious adverse drug reaction in tuberculosis (TB) patients receiving anti-TB drugs, is one of the most challenging clinical problems worldwide. Despite increasing awareness of clinicians and public, even now it remains an enormous problem and causes of hospitalization and life-threatening events. Considering the importance of anti-TB drug-induced hepatotoxicity (DIH) as a maj...
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ژورنال
عنوان ژورنال: Clinics in Liver Disease
سال: 2017
ISSN: 1089-3261
DOI: 10.1016/j.cld.2016.08.008